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Sitego,

<?php

$file = 'file.txt';

$lines = file($file, FILE_IGNORE_NEW_LINES | FILE_SKIP_EMPTY_LINES);

$str = 'delete this';

$array = array();

foreach($lines as $line) {
    if (!preg_match('/' . $str . '/', $line)) {
        $array[] = $line;
    }
}

file_put_contents('new_file.txt', implode(PHP_EOL, $array));